University of Geneva - Faculty of Medicine

Department of Microbiology and Molecular Medicine
Head of Department : Pr Patrick Linder

 

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The Linder Lab


Pr. P. LINDER 
CMU/ Dpt MIMOL 
Rue Michel-Servet 1 
1211 Genève 4 
Suisse 
Patrick.Linder@unige.ch 
Tel.: 022 379 54 84 
Fax: 022 379 55 02 
 
Research's subject Group's publications Team's members To Find
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Group's publications
New range of vectors with a stringent 5-fluoroorotic acid-based counterselection system for generating mutants by allelic replacement in Staphylococcus aureus. 
APPLIED AND ENVIRONMENTAL MICROBIOLOGY 
2012 vol. 78(11) pp. 3846-3854 
REDDER P, LINDER P 

The CodY pleiotropic repressor controls virulence in gram-positive pathogens. 
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY 
2011 vol. 62(2) pp. 123-139 
STENZ L, FRANCOIS P, WHITESON K, WOLZ C, LINDER P, SCHRENZEL J 

Analyses of the functional regions of DEAD-box RNA "helicases" with deletion and chimera constructs tested in vivo and in vitro. 
JOURNAL OF MOLECULAR BIOLOGY 
2011 vol. 413(2) pp. 451-472 
BANROQUES J, CORDIN O, DOERE M, LINDER P, TANNER NK 

From unwinding to clamping - the DEAD box RNA helicase family. 
NATURE REVIEWS MOLECULAR CELL BIOLOGY 
2011 vol. 12(8) pp. 505-516 
LINDER P, JANKOWSKY E 

A type IV modification-dependent restriction enzyme SauUSI from Staphylococcus aureus subsp. aureus USA300. 
NUCLEIC ACIDS RESEARCH 
2011 vol. 39(13) pp. 5597-5610 
XU SY, CORVAGLIA AR, CHAN SH, ZHENG Y, LINDER P 

Power of yeast for analysis of eukaryotic translation initiation. 
JOURNAL OF BIOLOGICAL CHEMISTRY 
2010 vol. 285(42) pp. 31907-31912 
ALTMANN M, LINDER P 

Motif III in superfamily 2 "helicases" helps convert the binding energy of ATP into a high-affinity RNA binding site in the yeast DEAD-box protein Ded1. 
JOURNAL OF MOLECULAR BIOLOGY 
2010 vol. 396(4) pp. 949-966 
BANROQUES J, DOERE M, DREYFUS M, LINDER P, TANNER NK 

A type III-like restriction endonuclease functions as a major barrier to horizontal gene transfer in clinical Staphylococcus aureus strains. 
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 
2010 vol. 107(26) pp. 11954-11958 
CORVAGLIA AR, FRANCOIS P, HERNANDEZ D, PERRON K, LINDER P, SCHRENZEL J 

Linear ubiquitin fusion to Rps31 and its subsequent cleavage are required for the efficient production and functional integrity of 40S ribosomal subunits 
MOLECULAR MICROBIOLOGY 
2009 vol. 72(1) pp. 69-84 
LACOMBE T, GARCIA-GOMEZ JJ, DE LA CRUZ J, ROSER D, HURT E, LINDER P, KRESSLER D 

Plant RNA helicases: linking aberrant and silencing RNA. 
TRENDS IN PLANT SCIENCE 
2009 vol. 14(6) pp. 344-352 
LINDER P, OWTTRIM GW 

mRNA export: RNP remodeling by DEAD-box proteins. 
CURRENT BIOLOGY 
2008 vol. 18(7) pp. 297-299 
LINDER P 

Impact of oleic acid (cis-9-octadecenoic acid) on bacterial viability and biofilm production in Staphylococcus aureus. 
FEMS MICROBIOLOGY LETTERS 
2008 vol. 287(2) pp. 149-155 
STENZ L, FRANÇOIS P, FISCHER A, HUYGHE ANTOINE, TANGOMO M, HERNANDEZ D, CASSAT J, LINDER P, SCHRENZEL J 

A conserved phenylalanine of motif IV in superfamily 2 helicases is required for cooperative, ATP-dependent binding of RNA substrates in DEAD-box proteins. 
MOLECULAR AND CELLULAR BIOLOGY : MCB 
2008 vol. 28(10) pp. 3359-3371 
BANROQUES J, CORDIN O, DOERE M, LINDER P, TANNER NK 

Membrane stress is coupled to a rapid translational control of gene expression in chlorpromazine-treated cells 
CURRENT GENETICS 
2007 vol. 52 pp. 171-185 
DE FILIPPI L, FOURNIER M, CAMERONI E, LINDER P, DE VIRGILIO C, FOTI M, DELOCHE O 

A copper-activated two-component system interacts with zinc and imipenem resistance in Pseudomonas aeruginosa 
JOURNAL OF BACTERIOLOGY 
2007 vol. 189 pp. 4561-4568 
CAILLE, O, ROSSIER, C, PERRON, K 

Bent out of shape: RNA unwinding by the DEAD-box helicase Vasa 
CELL 
2006 vol. 125(2) pp. 219-221 
LINDER PATRICK, LASKO PAUL 

Leishmania infantum LeIF protein is an ATP-dependent RNA helicase and an eIF4A-like factor that inhibits translation in yeast 
FEBS JOURNAL 
2006 vol. 273(22) pp. 5086-5100 
BARHOUMI M, TANNER NK, BANROQUES J, LINDER P, GUIZANI I 

The DEAD-box protein family of RNA helicases 
GENE 
2006 vol. 367 pp. 17-37 
CORDIN O, BANROQUES J, TANNER NK, LINDER P 

Unwinding single RNA molecules using helicases involved in eukaryotic translation initiation
JOURNAL OF MOLECULAR BIOLOGY 
2006 vol. 361(2) pp. 327-335 
MARSDEN STEVEN, NARDELLI MARIA, LINDER PATRICK, MCCARTHY JOHN E.G. 

A novel multifunctional factor involved in trans-splicing of chloroplast introns in Chlamydomonas 
NUCLEIC ACIDS RESEARCH 
2006 vol. 34(1) pp. 262-274 
MERENDINO LIVIA, PERRON KARL, RAHIRE MICHELE, HOWALD ISABELLE, ROCHAIX JEAN-DAVID, GOLDSCHMIDT-CLERMONT MICHEL 

Dead-box proteins: a family affair - active and passive players in RNP-remodeling 
NUCLEIC ACIDS RESEARCH 
2006 vol. 34 pp. 4168-4180 
LINDER P 

Sen34p depletion blocks tRNA splicing in vivo and delays rRNA processing 
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 
2005 vol. 337 pp. 89-94 
VIVIANA VOLTA, MARCELLO CECI, EMERY BERTRAND, ANGELA BACHI, ELISABETH PETFALSKI, DAVID TOLLERVEY, LINDER PATRICK, PIER CARLO MARCHISIO 

Belle is a Drosophila DEAD-box protein required for viability and in the germ line 
DEVELOPMENTAL BIOLOGY 
2005 vol. 277(1) pp. 92-101 
JOHNSTONE O, DEURING R, BOCK R, LINDER PATRICK, FULLER MT, LASKO P 

Characterization of the ATPase and unwinding activities of the yeast DEAD-box protein Has1p and the analysis of the roles of the conserved motifs 
NUCLEIC ACIDS RESEARCH 
2005 vol. 33(3) pp. 999-1009 
ROCAK SANDA, EMERY BERTRAND, TANNER NK, LINDER PATRICK 

The newly discovered Q motif of DEAD-box RNA helicases regulates RNA-binding and helicase activity 
EMBO JOURNAL 
2004 vol. 13 pp. 2478-2487 
CORDIN O, TANNER NK, DOERE M, LINDER P, BANROQUES J 

The putative RNA helicase Dbp6p functionally interacts with Rpl3p, Nop8p and the novel trans-acting Factor Rsa3p during biogenesis of 60S ribosomal subunits in Saccharomyces cerevisiae 
GENETICS 
2004 vol. 166 pp. 1687-1699 
DE LA CRUZ, LACOMBE T, DELOCHE OLIVIER, LINDER PATRICK, KRESSLER D 

A membrane transport defect leads to a rapid attenuation of translation initiation in Saccharomyces cerevisiae 
MOLECULAR CELL 
2004 vol. 13 pp. 357-366 
DELOCHE OLIVIER, JESUS DE LA CRUZ, KRESSLER DIETER, DOERE MONIQUE, LINDER PATRICK 

Has 1p, a member of the DEAD-box family, is required fo 40S ribosomal subunit biogenesis in Saccharomyces cerevisiae 
MOLECULAR MICROBIOLOGY 
2004 vol. 52 pp. 141-158 
EMERY B, DE LA CRUZ J, ROCAK S, DELOCHE OLIVIER, LINDER PATRICK 

DEAD-box proteins : the driving forces behind RNA metabolism 
NATURE REVIEWS MOLECULAR CELL BIOLOGY 
2004 vol. pp. 232-241 
ROCAK S, LINDER PATRICK 

Crystal structure of the human ATP-dependent splicing and export factor UAP56 
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 
2004 vol. 101 pp. 17628-17633 
SHI H, CORDIN O, MINDER CM, LINDER PATRICK, XU RM 

The Life of RNA with Proteins 
SCIENCE 
2004 vol. 304 pp. 694-695 
LINDER PATRICK 

The Q motif: a newly identified motif in DEAD box helicases may regulate ATP binding and hydrolysis. 
MOLECULAR CELL 
2003 vol. 11 pp. 127-138 
TANNER NK, CORDIN O, BANROQUES J, DOERE M, LINDER P 

Zinc is required for the catalytic activity of the human deubiquitinating isopeptidase T 
BIOCHEMISTRY (JOHN WILEY & SONS) 
2002 vol. 41 pp. 13755-13766 
GABRIEL JM, LACOMBE T, CAROBBIO S, PAQUET N, BISIG R, COX JA, JATON JC 

Further characterization of the putative human isopeptidase T catalytic site 
FEBS LETTERS 
2002 vol. 531 pp. 469-474 
LACOMBE T, GABRIEL JM 

A yeast homolog of chromatin assembly factor 1 is involved in early ribosome assembly 
CURRENT BIOLOGY : CB 
2001 vol. 11 pp. 1885-1890 
SCHAPERS, FROMONT-RACINE M, LINDER P, DE LA CRUZ J, NAMANE A, YANIV M 

mRNA export: Travelling with DEAD-box proteins 
CURRENT BIOLOGY : CB 
2001 vol. 11 pp. 0- 
LINDER P, STUTZ F 

DExD/H-Box RNA helicases: From Generic Motors to Specific Dissociation Functions 
MOLECULAR CELL 
2001 vol. 8 pp. 251-262 
TANNER NK 2001. ., LINDER P 

Characterization and mutational analysis of yeast Dbp8p, a putative RNA helicase involved in ribosome biogenesis 
NUCLEIC ACIDS RESEARCH 
2001 vol. 29 pp. 1144-1155 
DAUGERON MC, LINDER P 

Dbp9p, a putative ATP-dependent RNA helicase involved in 60S-ribosomal-subunit biogenesis, functionally interacts with Dbp6p 
RNA (NEW YORK, N.Y.) 
2001 vol. 7 pp. 1317-1334 
DAUGERON MC, KRESSLER D, LINDER P 

From RNA helicases to RNPases 
TRENDS IN BIOCHEMICAL SCIENCES 
2001 vol. 26 pp. 339-341 
LINDER P, TANNER NK, BANROQUES J 
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