University of Geneva - Faculty of Medicine

Department of Microbiology and Molecular Medicine
Head of Department : Pr Patrick Linder



Research Groups

Martine Collart

Joseph Curran

Dominique Garcin

Patrick Linder

Dominique Soldati-Favre

Michel Strubin

Patrick Viollier

Jérome Pugin

Christian Van Delden

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The Garcin Lab

Rue Michel-Servet 1 
1211 Genève 4 
Tel.: 022 379 56 76 
Fax: 022 379 55 02 
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Research's subject
Molecular virology and innate immunity  

.After natural barriers represented by mucosa and skin, innate immunity is the first line of defense against viral infections. This line of defense is particularly important since it stops 99% of infections and is an absolutely requisit for the development of adaptive immunity, the other arm of our defense system which operates in a second stage of the infection. Intimate knowledge of the mechanisms that govern these interactions between viruses and innate defense system is therefore essential knowing that we are often disarmed in terms of antivirals compounds against these viral infections. In the laboratory we are primarily interested in the molecular mechanisms governing the specific detection of viral infections mainly at the level of viral nucleic acid detection in the cytoplasm of infected cells. The specificity of this detection is essential to trigger appropriate antiviral cellular responses and also delicate concerning viruses. The aim is to detect specific viral molecular signatures in a compartment naturally full of cellular nucleic acids. Another aspect of our research concerns the viral strategies to avoid or escape these innate responses so effective.