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| The Pugin Lab | |||
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Dr. J. PUGIN CMU/ Dpt MIMOL Rue Michel-Servet 1 1211 Genève 4 Suisse Jerome.Pugin@unige.ch Tel.: 022 379 56 84 / 86 |
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| Research's subject | Group's publications | Team's members | To Find |
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| Group's publications | |||
| The role of MD-2 in the opsonophagocytosis of Gram-negative bacteria CURRENT OPINION IN INFECTIOUS DISEASES 2009 vol. 22(3) pp. 286-291 TISSIERES P, PUGIN J Year in review in Intensive Care Medicine, 2008: I. Brain injury and neurology, renal failure and endocrinology, metabolism and nutrition, sepsis, infections and pneumonia. INTENSIVE CARE MEDICINE 2009 vol. 35(1) pp. 30-44 ANTONELLI M. AND AL. Year in review in Intensive Care Medicine, 2008: II. Experimental, acute respiratory failure and ARDS, mechanical ventilation and endotracheal intubation. INTENSIVE CARE MEDICINE 2009 vol. 35(2) pp. 215-231 ANTONELLI M. AND AL. Year in review in Intensive Care Medicine, 2008: III. Paediatrics, ethics, outcome research and critical care organization, sedation, pharmacology and miscellanea. INTENSIVE CARE MEDICINE 2009 vol. 35(3) pp. 405-416 ANTONELLI M. AND AL. Cooperation between PU.1 and CAAT/Enhancer-binding Protein beta Is Necessary to Induce the Expression of the MD-2 Gene JOURNAL OF BIOLOGICAL CHEMISTRY 2009 vol. 284(39) pp. 26261-26272 TISSIERES P, ARAUD T, OCHODA A, DRIFTE G, DUNN-SIEGRIST I, PUGIN J Long-term prognosis after acute kidney injury requiring renal replacement therapy. NEPHROLOGY, DIALYSIS, TRANSPLANTATION : OFFICIAL PUBLICATION OF THE EUROPEAN DIALYSIS AND TRANSPLANT ASSOCIATION - EUROPEAN RENAL ASSOCIATION 2009 vol. 24(7) pp. 2186-2189 TRIVERIO PA, MARTIN PY, ROMANS J, PUGIN J, PERNEGER T, SAUDAN P Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2008 vol. 177(5) pp. 498-505 NOBRE V, HARBARTH S, GRAF JEAN-DANIEL, ROHNER P, PUGIN J Cyclic stretch of human lung cells induces an acidification and promotes bacterial growth. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 2008 vol. 38(3) pp. 362-370 PUGIN J, DUNN-SIEGRIST I, DUFOUR J, TISSIERES P, CHARLES PE, COMTE R Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteria. BLOOD 2008 vol. 111(4) pp. 2122-2131 TISSIERES P, DUNN-SIEGRIST I, SCHAPPI MG, ELSON G, COMTE R, NOBRE V, PUGIN J Role of proinflammatory activity contained in gastric juice from intensive care unit patients to induce lung injury in a rabbit aspiration model. CRITICAL CARE MEDICINE 2008 vol. 36(12) pp. 3205-3212 BRÉGEON F, PAPAZIAN L, DELPIERRE S, KAJIKAWA O, PAYAN MJ, MARTIN TR, KIPSON N, PUGIN J Dear SIRS, the concept of "alarmins" makes a lot of sense! INTENSIVE CARE MEDICINE 2008 vol. 34(2) pp. 218-221 PUGIN J Profiling genes in the ICU: are we there yet? INTENSIVE CARE MEDICINE 2008 vol. 34(8) pp. 1357-1359 PUGIN J Year in review in Intensive Care Medicine, 2007. I. Experimental studies. Clinical studies: brain injury and neurology, renal failure and endocrinology. INTENSIVE CARE MEDICINE 2008 vol. 34(2) pp. 229-242 ANTONELLI M AND AL. Year in review in Intensive Care Medicine, 2007. II. Haemodynamics, pneumonia, infections and sepsis, invasive and non-invasive mechanical ventilation, acute respiratory distress syndrome. INTENSIVE CARE MEDICINE 2008 vol. 34(3) pp. 405-422 ANTONELLI M AND AL. Year in review in Intensive Care Medicine, 2007. III. Ethics and legislation, health services research, pharmacology and toxicology, nutrition and paediatrics. INTENSIVE CARE MEDICINE 2008 vol. 34(4) pp. 598-609 ANTONELLI M AND AL. Increased release of sMD-2 during human endotoxemia and sepsis: a role for endothelial cells. MOLECULAR IMMUNOLOGY 2008 vol. 45(11) pp. 3268-3277 WOLFS TG, DUNN-SIEGRIST I, VAN'T VEER C, HODIN CM, GERMERAAD WT, VAN ZOELEN MA, VAN SUYLEN RJ, PEUTZ-KOOTSTRA CJ, ELSON G, PUGIN J, BUURMAN WA Contribution of Toll-like receptors to the innate immune response to Gram-negative and Gram-positive bacteria BLOOD 2007 vol. 109(4) pp. 1574-1578 ELSON G, DUNN-SIEGRIST I, DAUBEUF B, PUGIN J Prompt antibiotic administration and goal-directed hemodynamic support in patients with severe sepses and septic shock CURRENT OPINION IN CRITICAL CARE 2007 vol. 13 pp. 586-591 NOBRE V, SARASIN FP, PUGIN J Hemodynamics in experimental gastric juice induced aspiration pneumonitis INTENSIVE CARE MEDICINE 2007 vol. 33 pp. 300-307 FRAISSE A, BREGEON F, DELPIERRE S, GAUDART J, PAYAN MJ, PUGIN J, PAPAZIAN L Year in review in Intensive Care Medicine, 2006. I. Experimental studies. Clinical studies: brain injury, renal failure and endocrinology INTENSIVE CARE MEDICINE 2007 vol. 33 pp. 49-57 ANDREWS, P, AZOULAY, E, ANTONELLI, M, BROCHARD, L, BRUN-BUISSON, C, DE BACKER, D, DOBB, G, FAGON, JY, GERLACH, H, GROENEVELD, J, MACRAE, D, MANCEBO, J, METNITZ, P, NAVA, S, PUGIN, J, PINSKY, M, RADERMACHER, P, RICHARD, C Year in review in Intensive Care Medicine, 2006. II. Infections and sepsis, haemodynamics, elderly, invasive and noninvasive mechanical ventilation, weaning, ARDS INTENSIVE CARE MEDICINE 2007 vol. 33 pp. 214-229 ANDREWS, P, AZOULAY, E, ANTONELLI, M, BROCHARD, L, BRUN-BUISSON, C, DE BACKER, D, DOBB, G, FAGON, JY, GERLACH, H, GROENEVELD, J, MACRAE, D, MANCEBO, J, METNITZ, P, NAVA, S, PUGIN, J, PINSKY, M, RADERMACHER, P, RICHARD, C Year in Review in Intensive Care Medicine, 2006. III. Circulation, ethics, cancer, outcome, education, nutrition, and pediatric and neonatal critical care INTENSIVE CARE MEDICINE 2007 vol. 33 pp. 414-422 ANDREWS P, AZOULAY E, ANTONELLI M, BROCHARD L, BRUN-BUISSON C, DE BACKER D, DOBB G, FAGON JY, GERLACH H, GROENEVELD J, MACRAE D, MANCEBO J, METNITZ P, NAVA S, PUGIN J, PINSKY M, RADERMACHER P, RICHARD C Pivotal involvement of Fcgamma receptor IIA in the neutralization of lipopolysaccharide signaling via a potent novel anti-TLR4 monoclonal antibody 15C1 JOURNAL OF BIOLOGICAL CHEMISTRY 2007 vol. 282(48) pp. 34817-34827 DUNN-SIEGRIST I, LEGER O, DAUBEUF B, POITEVIN Y, DÉPIS F, HERREN S, KOSCO-VILBOIS M, DEAN Y, PUGIN J, ELSON G Nonketotic hyperglycemic coma in toddlers after unintentional methadone ingestion ANNALS OF EMERGENCY MEDICINE 2006 vol. 48 pp. 448-451 TIRAS S, HAAS V, CHEVRET L, DECOBERT M, BUISINE A, DEVICTOR D, DURAND P, TISSIERES P Evaluation of rapid screening and pre-emptive contact isolation for detecting and controlling methicillin-resistant Staphylococcus aureus in critical care: an interventional cohort study CRITICAL CARE 2006 vol. 10(1) pp. 25-25 HARBARTH S, MASUET-AUMATELL C, SCHRENZEL J, FRANCOIS P, AKAKPO C, RENZI G, PUGIN J, RICOU B, PITTET D Endocan, a new endothelial marker in human sepsis CRITICAL CARE MEDICINE 2006 vol. 34 pp. 532-537 SCHERPEREEL A, DEPONTIEU F, GRIGORIU B, CAVESTRI M, TSICOPOULOS A, GENTINA T, JOURDAIN M, PUGIN J, TONNEL AB, LASSALLE P Is the measurement of monocytes HLA-DR expression useful in patients with sepsis? INTENSIVE CARE MEDICINE 2006 vol. 32 pp. 1106-1108 FUMEAUX T, PUGIN J Year in review in intensive care medicine. 2005. I. Acute respiratory failure and acute lung injury, ventilation, hemodynamics, education, renal failure INTENSIVE CARE MEDICINE 2006 vol. 32 pp. 207-216 ANDREWS P, AZOULAY E, ANTONELLI M, BROCHARD L, BRUN-BUISSON C, DE BACKER D, DOBB G, FAGON JY, GERLACH H, GROENEVELD J, MANCEBO J, METNITZ P, NAVA S, PUGIN J, PINSKY M, RADERMACHER P, RICHARD C Year in review in intensive care medicine, 2005. II. Infection and sepsis, ventilator-associated pneumonia, ethics, haematology and haemostasis, ICU organisation and scoring, brain injury INTENSIVE CARE MEDICINE 2006 vol. 32 pp. 380-390 ANDREWS P, AZOULAY E, ANTONELLI M, BROCHARD L, BRUN-BUISSON C, DOBB G, FAGON JY, GERLACH H, GROENEVELD J, MANCEBO J, METNITZ P, NAVA S, PUGIN J, PINSKY M, RADERMACHER P, RICHARD C, TASKER R Year in review in intensive care medicine, 2005. III. Nutrition, pediatric and neonatal critical care, and experimental INTENSIVE CARE MEDICINE 2006 vol. 32 pp. 490-500 ANDREWS P, AZOULAY E, ANTONELLI M, BROCHARD L, BRUN-BUISSON C, DOBB G, FAGON JY, GERLACH H, GROENEVELD J, MANCEBO J, METNITZ P, NAVA S, PUGIN J, PINSKY M, RADERMACHER P, RICHARD C, TASKER R Comparison of classifications for heart failure in children undergoing valvular surgery JOURNAL OF PEDIATRICS 2006 vol. 149 pp. 210-215 TISSIERES P, AGGOUN Y, DA CRUZ E, SIERRA J, MENSI N, KALANGOS A, BEGHETTI M Adding a dialysis dose to continuous hemofiltration increases survival in patients with acute renal failure KIDNEY INTERNATIONAL 2006 vol. 70 pp. 1312-1317 SAUDAN P, NIEDERBERGER M, DE SEIGNEUX S, ROMAND J, PUGIN J, PERNEGER T, MARTIN PY Increase of fungal endocarditis in children INFECTION 2005 vol. 33 pp. 267-272 TISSIERES PIERRE, JAEGGI EDGARD, BEGHETTI MAURICE, GERVAIX ALAIN Year in review in intensive care medicine, 2004. II. Brain injury, hemodynamic monitoring and treatment, pulmonary embolism, gastrointestinal tract, and renal failure INTENSIVE CARE MEDICINE 2005 vol. 31(2) pp. 177-188 ANDREWS P, AZOULAY E, ANTONELLI M, BROCHARD L, BRUN-BUISSON C, DOBB G, FAGON JY, GERLACH H, GROENEVELD J, MANCEBO J, METNITZ P, NAVA S, PUGIN J, PINSKY M, RADERMACHER P, RICHARD C, TASKER R, VALLET B Role of MAP kinase activation in interleukin-8 production by human BEAS-2B bronchial epithelial cells submitted to cyclic stretch CELLULAR & MOLECULAR BIOLOGY RESEARCH 2002 vol. 27 pp. 107-114 OUDIN S, PUGIN J Molecular mechanisms of lung cell activation induced by cyclic stretch CRITICAL CARE MEDICINE 2002 vol. 31 pp. 200-206 PUGIN J Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: a randomized controlled pilot study JOURNAL OF HEPATOLOGY 2002 vol. 37 pp. 448-455 SPAHR L, RUBBIA-BRANDT L, FROSSARD JL, GIOSTRA E, ANNE-LAURE ROUGEMONT, PUGIN J, MARIA FISCHER, HANSPETER EGGER, HADENGUE A Clinical signs and scores for the diagnosis of ventilator-associated pneumonia MINERVA ANESTESIOLOGICA 2002 vol. 68 pp. 261-265 PUGIN J. Role of interleukin-10 in the intracellular sequestration of human leukocyte antigen-DR in monocytes during septic shock RESPIRATORY CARE 2002 vol. 166 pp. 1475-1482 FUMEAUX T, PUGIN J Conventional mechanical ventilation of healthy lungs induced pro-inflammatory cytokine gene transcription RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY 2002 vol. 132 pp. 191-203 BREGEON F, ROCH A, DELPIERRE S, GHIGO E, AUTILLO-TOUATI A, KAJIKAWA O, MARTIN TR, PUGIN J, PORTUGAL H, AUFFRAY JP, JAMMES Y Increased angiostatin levels in bronchoalveolar lavage fluids from ARDS patients and from human volunteers after lung instillation of endotoxin. Luca R, Lijnen HR, Suffredini AF, Pepper MS, Steinbe rg KP, Martin TR, Pugin J. THROMBOSIS AND HAEMOSTASIS 2002 vol. 87(6) pp. 966-971 LUCA R, LIJNEN HR, SUFFREDINI AF, PEPPER MS, STEINBERG KP, MARTIN TR, PUGIN J Cytokine balance in the lungs of patients with the acute respiratory distress syndrome AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2001 vol. 164 pp. 1896-1903 PARK WY, GOODMAN R, STEINBERG K, RUZINSKI JT, RADELLA II F, PAEK RD, PUGIN J, SKERETT SJ, HUDSON LD, MARTIN TR Diagnostic value of procalcitonin, interleukin (IL)-6 ans IL-8 in critically ill patients admitted with suspected sepsis AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2001 vol. 164 pp. 396-402 HARBARTHS, HOLECKOVA K, FROIDEVAUX C, PITTET D, RICOU B, GRAU GE, VADAS L, PUGIN J, AND THE GENEVA SEPSIS NETWORK Local inflammatory responses following bronchial endotoxin instillation in humans AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2001 vol. 163 pp. 1591-1598 O'GRADY NP, PREAS HL, PUGIN J, FIUZA C, TROPEA M, REDA C, BANKS SM, SUFFREDINI AF Normal responses to injury prevent systemic inflammation and can be immunosuppressive AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2001 vol. 163 pp. 316-321 MUNFORD RS, PUGIN J Pulmonary edema fluid from patients with acute lung injury augments epithelial repair by an IL-1B dependant mechanism. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2001 vol. 163 pp. 1384-1388 GEISER T, ATABAI K, JARREAU PH, WARE BL, PUGIN J, MATTHAY MA Procalcitonin is not an accurate marker of spontaneous bacterial peritonitis in patients with cirrhosis GASTROENTEROLOGY 2001 vol. 48 pp. 502-505 SPAHR L, MORARD A, HADENGUE A, VADAS L, PUGIN J The role of systemic responses in the innate (non-adaptive) host defense JOURNAL OF ENDOTOXIN RESEARCH 2001 vol. 7 pp. 327-332 MUNFORD RS, PUGIN J Rapid changes in alcoholic hepatitis histology under steroids: correlation with soluble intercellular adhesion molecule-1 in hepatic venous blood JOURNAL OF HEPATOLOGY 2001 vol. 35 pp. 582-589 SPAHR L, RUBBIA-BRANDT L, PUGIN J., GIOSTRA E, FROSSARD JL, BORISCH B, HADENGUE A Inflammation, coagulation et sepsis MEDECINE ET HYGIENE : JOURNAL SUISSE D'INFORMATIONS MEDICALES 2001 vol. 59 pp. 2479-2484 FUMEAUX T, PUGIN J Modulation of choline acetyltransferase synthesis by okadaic acid, a phosphatase inhibitor, and KN-62, a CaM kinase inhibitor, in NS-20Y neuroblastoma NEUROCHEMISTRY INTERNATIONAL 2001 vol. 38 pp. 75-82 PAHUD G, BONTRON S, EDER-COLLI L |
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